Type 2 diabetes drugs that include saxagliptin and alogliptin may increase the risk of heart failure, particularly in patients with a history of heart or kidney disease, according to the U.S. Food & Drug Administration (FDA), which has announced new warnings for the drugs’ labeling.
Free Confidential Lawsuit Evaluation: If you or a loved one was diagnosed with heart failure after taking a DPP-4 diabetes medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.
What’s the problem?
April 5, 2016 – The new heart failure warning applies to type 2 diabetes drugs from the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Affected medications include:
- Onglyza (saxagliptin)
- Kombiglyze XR (saxagliptin and metformin extended release)
- Nesina (alogliptin)
- Oseni (alogliptin and pioglitazone)
“Healthcare professionals should consider discontinuing medications containing saxagliptin and alogliptin in patients who develop heart failure and monitor their diabetes control,” FDA said. “If a patient’s blood sugar level is not well-controlled with his or her current treatment, other diabetes medicines may be required.”
The new warnings are based on FDA’s evaluation of 2 large clinical trials involving patients with heart disease. Both trials found that more patients who took saxagliptin or alogliptin-containing medications were hospitalized for heart failure, compared to patients who received a placebo. In the saxagliptin trial, 3.5% of patients treated with the drug were hospitalized for heart failure, compared with 2.8% of patients given a placebo. Risk factors included a pre-existing history of heart failure or kidney impairment. In the alogliptin trial, 3.9% of patients who received alogliptin were hospitalized for heart failure, compared with 3.3% for the placebo.
Heart Failure Symptoms
Signs and symptoms of heart failure may include:
- Unusual shortness of breath during daily activities
- Trouble breathing when lying down
- Tiredness, weakness or fatigue
- Weight gain / swelling in the ankles, feet, legs, or stomach
FDA advises DPP-4 inhibitor users to contact their doctor immediately if they begin experiencing any of these symptoms. However, you should never quit taking or switch prescription medications without talking to your doctor first.
Do I Have a Diabetes Drug Heart Failure Lawsuit?
The Class Action Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in diabetes drug injury lawsuits. We are handling individual litigation nationwide and currently accepting new heart failure cases in all 50 states.
Free Confidential Lawsuit Evaluation: Again, if you suffered heart failure after taking a type 2 diabetes medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit and we can help.