People who take proton pump inhibitor (PPI) drugs for heartburn, acid reflux or ulcers may have an increased risk of developing chronic kidney disease (CKD), acute interstitial nephritis (AIN) and renal failure, according to a new study. PPIs include Nexium (esomeprazole), Aciphex (rabeprazole), Protonix (pantoprazole), Prevacid (lansoprazole), Zegerid (omeprazole / sodium bicarbonate), Dexilant (dexlansoprazole) and Prilosec (omeprazole).
Free Confidential Lawsuit Evaluation: If you or a loved one suffered kidney damage after taking a heartburn medication, you should contact our law firm immediately. You may be entitled to compensation by filing a suit against the manufacturer and our lawyers can help.
Update: Study Links PPIs to Increased Stroke Risk
November 16, 2016 – A study presented Tuesday at the annual meeting of the American Heart Association (AHA) in New Orleans found that proton pump inhibitors increased a user’s overall risk of stroke by 21%. However, this risk appears to be largely driven by patients who take high doses of the medications. At the highest dose, stroke risk ranged from 30% with Prevacid to 94% with Protonix, according to the study.
What’s the Problem?
April 14, 2016 – For the study, which was published online today in the Journal of the American Society of Nephrology (JASN), a research team led by Yan Xie, MPH and Ziyad Al-Aly, MD, FASN (Clinical Epidemiology Center at the VA Saint Louis Health Care System and Washington University in St. Louis) looked at data from the Department of Veterans Affairs national databases. They identified 173,321 new PPI users and 20,270 new users of histamine H2 receptor blockers, another class of drug used to suppress stomach acid.
Over 5 years of follow-up, those who used proton pump inhibitors were more likely to suffer kidney function decline compared to those who took H2 receptor blockers. PPI users also had a 28% increased risk of developing chronic kidney disease (CKD) and a 96% increased risk of kidney failure (renal failure or end-stage renal disease). Additionally, there was a graded association between duration of PPI use and risk of kidney issues, with those who took the drugs for a longer period of time being more likely to suffer kidney problems.
The study suggests that long-term PPI use may be harmful to the kidneys and should be avoided. Proton pump inhibitors may not only increase the risk of CKD, but also of complete kidney failure, a potentially fatal condition that requires either dialysis or a kidney transplant to treat.
“The results emphasize the importance of limiting PPI use only when it is medically necessary, and also limiting the duration of use to the shortest duration possible,” said Dr. Al-Aly. “A lot of patients start taking PPIs for a medical condition, and they continue much longer than necessary.”
Proton Pump Inhibitors Linked to hypomagnesemia in Dialysis Patients
July 14, 2016 – PPI use has been linked to low serum magnesium levels (hypomagnesemia), which in the presence of inflammation are associated with increased 1-year mortality risk, according to a new study published in Hemodialysis International. Researchers looked at data on 399 dialysis patients, 243 of whom were being treated with PPIs, and found that mean serum magnesium levels were significantly lower in PPI users compared to non-users (2.39 vs. 2.56 mg/dL).
Do I Have a Proton Pump Inhibitor Lawsuit?
The Class Action Litigation Group at our law firm is an experienced team of trial lawyers that focus on the representation of plaintiffs in PPI lawsuits. We are handling individual litigation nationwide and currently investigating potential settlements in all 50 states.
Free Confidential Case Evaluation: Again, if you were injured by the side effects of a proton pump inhibitor, you should contact our law firm immediately. You may be entitled to a settlement by filing a suit and our lawyers can help.